Fri Dec 05 2025

86 articles - From Friday Nov 28 2025 to Friday Dec 05 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Endoscopy
Curriculum for safe and effective use of artificial intelligence in endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.

The proposed framework defines the prerequisites in the preadoption phase, core training components, and requirements to maintain optimal implementation. Key recommendations include: (1) ensuring basic competency in standard endoscopy procedures; (2) acquiring foundational knowledge of AI principles; (3) implementing educational programs to enhance AI literacy; (4) recognizing and mitigating cognitive biases in human-AI interaction; (5) avoiding over-reliance on AI in clinical decision-making; and (6) continuous monitoring of key performance indicators throughout AI system integration.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther
Systematic Review: Efficacy, Safety and Metabolic Outcomes of GLP-1 Receptor Agonists in Inflammatory Bowel Disease.

GLP-1 RAs appear to be well tolerated in patients with IBD, with observational evidence suggesting potential associations with improved weight, metabolic, and disease-related outcomes. Prospective, IBD-specific studies are required to confirm safety, clarify mechanisms, and define optimal patient selection.

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Am J Gastroenterol
Barriers and Facilitators of Alcohol Use Disorder Treatment for Alcohol-associated Liver Disease: A Systematic Review.

To increase AUD treatment in ALD, we suggest to (1) Deepen patient and provider insights on AUD treatment during asymptomatic and symptomatic ALD, (2) Normalize AUD treatment for LT candidates and recipients, (3) Apply choice architecture and address misunderstandings about MAUD, (4) Improve collaborative care models accounting for patient preferences.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther
Diabetes Mellitus is a Risk Factor for Hepatic Encephalopathy Following Transjugular Intrahepatic Portosystemic Shunt.

This study highlights the high incidence of HE following TIPS and shows that DM is a significant and independent risk factor for the development of HE. Given the increase in patients with metabolic dysfunction-associated liver cirrhosis and DM, this study offers additional insights into the balance of risks and benefits associated with TIPS placement.

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Hepatitis B Virus RNA Predicts Hepatocellular Carcinoma Despite Viral Suppression.

HBV RNA levels at viral suppression predict HCC development in NA-treated patients with CHB, outperforming HBcrAg. Incorporating HBV RNA assessment can improve risk-stratified HCC surveillance strategies.

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Intestinal Ultrasound Transmural Healing Was Associated With Improved Long-Term Outcomes Among Patients With Endoscopic Remission: Results of a Prospective Study.

IUS TH was associated with improved long-term outcomes with lower risks of CD relapse, hospitalization, and perianal CD.

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Patient Plasma-Induced Neutrophil Dysfunction Is Associated With Infection Risk and Mortality in Patients With Acute Decompensation of Cirrhosis.

Plasma from patients with AD induces a 'primed but exhausted' neutrophil phenotype, characterised by a paradoxical failure to respond to stimuli. This dysfunction was associated with an increased risk of infection and mortality, particularly in AD-NoACLF patients. PIND offers a promising strategy to improve risk stratification in this high-risk population.

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Serum Villin-1-A Novel Marker of Gut Barrier Damage in Acutely Decompensated Cirrhosis: A Cohort Study and Validation.

Serum VIL1 is a non-invasive indicator of gut barrier damage and short-term mortality in AD cirrhosis. Incorporating VIL1 assessment into risk stratification methods improves prognostic accuracy by capturing an essential, yet previously overlooked component of disease progression.

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Clin Gastroenterol Hepatol
High prevalence of disorders of irritable bowel syndrome and functional dyspepsia in night shift workers: a cross-sectional study in Australia and the UK.

Night shift workers have a substantially higher prevalence of IBS and FD compared to reported general population rates, with significant impacts on IBS-specific quality of life and mental health. These findings highlight the need for targeted interventions to support gastrointestinal and mental health in this vulnerable working population.

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Mental health diseases are associated with active hepatitis C and partly drive HCC trends in Veterans.

In a large cohort of Veterans with cirrhosis, any MHD significantly increased incident HCC risk and associated with active HCV, even in the post-DAA era, with AUD and ALD having the largest effects. Multidisciplinary management of vulnerable, at-risk Veterans is needed to mitigate the risk of HCC.

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Prevalence and Outcomes of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease: A Multinational Study across Asia.

PSC is less prevalent among Asian IBD patients than in Western populations. The increased use of MRCP may enable earlier detection, contributing to milder disease severity and improved clinical outcomes in recent years.

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The "A-B-C" classification reveals outcome trajectories in patients with hepatocellular carcinoma under atezolizumab/bevacizumab.

The Atezolizumab-Bevacizumab-Cluster (A-B-C) classification for unresectable HCC identified subgroups with histology, hepatic decompensation and patterns of progression, and prognostic trajectories, informing hypothesis generation for trial design and patient selection.

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Endoscopy
Safety and efficacy of traction robot-assisted endoscopic submucosal dissection for early gastric cancer: a randomized pilot trial.

Despite no significant difference in procedure time between robot-assisted and conventional ESD (58.21 vs 39.21 minutes; 0.99) resection rates between robot-assisted and conventional ESD, respectively. This preliminary evidence supports the feasibility of robot-assisted gastric ESD.

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Gastrointest Endosc
Optimal endoscopic treatment for rectal neuroendocrine tumors, confirmed after forceps biopsy: A Korean Association for the Study of Intestinal Diseases multicenter, randomized non-inferiority trial.

The m-EMR did not demonstrate non-inferiority to ESD for complete resection of biopsy-proven rectal NETs ≤10 mm. Thus, when both m-EMR and ESD are accessible, m-EMR may not be the preferred resection modality in patients subjected to pre-resection forceps biopsy. Further studies are needed to explore the potential role of m-EMR in resource-limited settings. (Trial number KCT0006881).

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Real-World Outcomes of Endoscopic Ultrasound-Guided Tissue Acquisition for Actionable Diagnosis in Suspected Primary or Recurrent Lymphoma.

EUS-guided biopsy is safe and yields accurate results in most patients with suspected lymphoma. In clinical practice, the use of EUS-guided biopsy for suspected recurrent lymphoma with a confirmed biopsy is increasing. These findings support its expanding role as a minimally invasive alternative diagnosis method.

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Superiority of Excellent Over Good Bowel Preparation for Proximal Serrated Polyp Detection in a FIT-Based Screening Cohort.

Aiming for an excellent rather than a good bowel preparation is a critical strategy to maximize the detection rate of serrated pathway lesions and potentially reduce the incidence and mortality for interval colorectal cancer (CRC). This benefit does not extend to adenoma detection, underscoring the importance of PSDR and SSLDR as distinct and complementary quality indicators.

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Gut
Discovery of a carboxyl fullerene derivative as a new lipid droplet regulator inhibiting MASLD.

This study provides proof-of-concept supporting a nanoparticle-based agent as a LD homeostasis-targeted therapeutic to treat MASLD and related metabolic diseases.

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Does a long time to colonoscopy after a positive faecal immunochemical test result have a deleterious impact on colorectal cancer outcomes? A nationwide cohort study.

No increased risk of CRC, advanced-stage CRC or AA was observed up to 24 months. Our findings suggest that ensuring colonoscopy compliance after a positive FIT may take precedence over rigid adherence to interval. The higher the f-Hb, the sooner the colonoscopy should be performed.

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Gut microbe alleviates stress-related cancer metastasis by oleic acid degradation.

Shotgun metagenomics and metabolomics were performed to assess changes in microbiota and metabolites. The effects of and OA may help prevent stress-related tumour progression.

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Intraperitoneal translocation of gut microbiota induces NETosis and promotes endometriosis.

Design We combined single-cell RNA sequencing of clinical peritoneal fluid immune cells with functional validation in heterologous and homologous mice models. We further adopted microbial source-tracking analysis of patient cohorts and interventional strategies, including faecal microbiota transplantation (FMT) and administration of green fluorescent protein (GFP)-tagged triggers NETosis in peritoneal Neu_MME to promote disease, suggesting that targeting this bacterium or NETosis represents a viable therapeutic strategy.

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Hepatology
Targeting mTORC2-Dependent AKT/FOXO1/RNF125 signaling exploits a therapeutic vulnerability in c-MET-activated and β-catenin-mutated hepatocellular carcinoma.

Our study, for the first time, established the mTORC2/AKT/FOXO1/RNF125 axis as a critical driver and therapeutic vulnerability in c-MET-activated/β-catenin-mutated HCC. Our study filled a critical gap by defining the tumor-suppressive role of FOXO1 specifically in this HCC subtype. Furthermore, our results positioned RNF125 as a promising therapeutic target for this aggressive HCC subtype.

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J Hepatol
A genome-wide siRNA screen identifies previously unknown proviral and antiviral host factors in HBV infection.

This study identifies NCOA5 and CHD4 as crucial proviral cofactors and NRAS as a potent antiviral factor regulating HBV replication. The findings highlight HBV's profound host dependence, uncover specific molecular mechanisms (involving HNF4A, epigenetic regulation of cccDNA, and cell cycle), and reveal validated host targets for potential therapeutic strategies against HBV infection.

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Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis.

Using data obtained on admission of patients with ADC without ACLF, this study uncovered that activation of maladaptive EG characterized patients who will develop ACLF by 28 days. Impact and implications This study reveals that among patients who present for acutely decompensated cirrhosis without acute-on-chronic liver failure (ACLF) those who exhibit blood transcriptomic features of maladaptive emergency granulopoiesis are at high risk of developing ACLF by 28 days and dying by 90 days. These results strongly suggest that neutrophil-granulopoietic perturbations play a pathogenic role in the development of poor outcomes. These results should lead to the development of biological therapies targeting neutrophil-granulopoietic perturbations, which is an unmet need. These findings should also give rise to the identification of potential biomarkers for ACLF development, which is also an unmet need, al previous studies having failed to accurately predict this outcome, in particular with the use of clinical blood counts.

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Targeting ATR to overcome cisplatin resistance in hepatoblastoma.

ATR mediates cisplatin resistance in HB. The combination of elimusertib and cisplatin demonstrated preclinical efficacy across patient-derived cultures and multiple in vivo HB models, supporting its potential as a promising therapy for cisplatin-resistant HB. Impact and implications () Chemoresistance significantly reduces survival in hepatoblastoma patients, highlighting the need for new therapies. In this study, we found that blocking ATR with the drug elimusertib synergizes with cisplatin, strongly reducing tumor growth in diverse preclinical models, including cell cultures and mouse models of cisplatin-resistant HB. These results highlight a promising new approach to improve outcomes for children with cisplatin-resistant HB and support further clinical evaluation.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther
Editorial for 'Review Article: Extending the Frontiers of Intestinal Ultrasound Knowledge, Performance, and Expansion'.

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Editorial: Caught in the Middle-Exploring the Grey Zone Between Decompensated and Recompensated HBV-Related Cirrhosis.

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Gastroenterology
The Role of Alcohol in Pancreatic Diseases: A Comprehensive Perspective.

Although behavioral strategies, such as abstinence, remain essential, pharmacologic and molecularly targeted therapies offer potential complementary approaches. Given the challenges of maintaining sustained abstinence, these adjunctive treatments are critical for slowing or preventing the progression of alcohol-driven pancreatic diseases.

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Gut
Decoding HBV-specific adaptive immunity: from natural clearance to cure.

However, recent preclinical and clinical studies have demonstrated only limited efficacy, underscoring major immunological challenges. In this review, we summarise current knowledge of the correlates of viral clearance and persistence, discuss key unresolved questions and outline future research directions needed to advance immune-based HBV cure strategies.

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J Hepatol
Optimal strategies to prevent disease progression and clinical events in MASLD.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol
2025 CME Information.

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Calendar of Courses, Symposiums and Conferences.

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Response to Lenti et al.

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Response to Limburg.

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Clin Gastroenterol Hepatol
Adherence to a Mediterranean diet predicts gastrointestinal and anxiety symptom response in irritable bowel syndrome.

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Cecal Dieulafoy Lesion.

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Endoscopy
"There is a time for everything".

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Accessory spleen masquerading as a gastric submucosal tumor: a rare case of diaphragmatic implantation post-splenectomy.

Pubmed   Journal   ReadQx   PMC

Acute pancreatitis following endoscopic hemostasis of a periampullary Dieulafoy lesion: successful rescue by endoscopic retrograde cholangiopancreatography.

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Antegrade enteral stenting for afferent loop syndrome using the double-guidewire technique via endoscopic ultrasound-guided hepaticogastrostomy.

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Band-ligation followed by anchor pronged clips for greater post-endoscopic submucosal dissection defect closure.

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Closing the defect after gastric endoscopic full-thickness resection with a novel linear-traction metal clip.

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Cold-endoscopic submucosal dissection: time to go further?

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Double-layered suturing using a reopenable-clip over-the-line method with a 20-mm reopenable clip to close a large gastric mucosal defect.

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Endoscopic vacuum therapy achieves complete resolution of anastomotic leakage after transanal total mesorectal excision in low rectal cancer: a full therapeutic course report.

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Endoscopy E-Videos - recently published.

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Hidden value of colon capsule endoscopy: balancing patient preference, environmental impact, and cost-effectiveness.

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Morphological features and not the timing determines the outcome of endoscopic ultrasound-guided transmural drainage of walled-off necrosis.

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Parenchymal loop technique using a novel 0.018-inch guidewire in endoscopic ultrasound-guided pancreatic duct drainage.

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Pre-emptive purse-string suture for full-thickness resection of a gastrointestinal stromal tumor in the duodenal bulb: a case report.

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Pre-sealing in different settings requires different modes.

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Radial incision and balloon dilation with triamcinolone filling for the severe rectal anastomotic stricture.

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Risks and opportunities: cholangioscopy-assisted strategic guidewire manipulation for the management of occlusive anastomotic stricture after liver transplantation.

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Salvage transmural lithotripsy via endoscopic ultrasound-guided hepaticogastrostomy for basket impaction in Roux-en-Y anatomy.

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Single versus multiple main or side-branch pancreatic duct cannulations: impact on post-ERCP pancreatitis.

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Stepwise super minimally invasive full-thickness resection of early rectal cancer: based on the handmade rubber traction technique.

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The adaptive traction doughnut resection technique for pyloric cancer: a case of curative resection and stenosis management.

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Underwater endoscopic submucosal resection with a ligation device for a duodenal neuroendocrine tumor.

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Virtual reality cross-sections matched to endoscopic ultrasound for preprocedural simulation of hepaticogastrostomy.

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Gastroenterology
Addressing Colonoscopy Burden due to Artificial Intelligence Devices for Polyp Detection.

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Advancing Medical Education: A Structured Approach to Faculty Development in Gastroenterology.

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Building a Culture of Excellence in Your Gastroenterology Fellowship: Creating a High VALUE Program.

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Esophageal Hypervigilance and Anxiety Predict Post-Treatment Outcomes in Achalasia.

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Gastrointest Endosc
EUS-choledochoduodenostomy in a rare case of Intraductal Papillary Mucinous Neoplasm (IPMN) associated biliary fistula.

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Endoscopic Hemostasis via Submucosal Polidocanol Injection: A New Paradigm for Hemorrhagic Radiation Proctopathy Management.

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Novel Use of Rigidizing Overtube for Direct Endoscopic Necrosectomy.

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Robot-assisted endoscopic full-thickness resection and defect closure for rectal neuroendocrine tumor (with video).

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Simultaneous peroral endoscopic myotomy and submucosal tunneling endoscopic resection in one submucosal tunnel for coexisting achalasia and esophageal submucosal tumor.

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Gut
SIRT6-GLUL axis: rewiring nitrogen metabolism in intrahepatic cholangiocarcinoma.

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Hepatology
From sex to size: Rethinking fairness in Liver Transplantation.

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Letter to the Editor: HBV DNA level of genuine immune-tolerant patients.

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Reply letter: Timing shapes adjuvant PD-1 efficacy after hepatectomy in HCC.

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J Hepatol
Stress-mediated brain-liver connection induces metabolic dysfunction.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther
Editorial: Caught in the Middle-Exploring the Grey Zone Between Decompensated and Recompensated HBV-Related Cirrhosis. Authors' Reply.

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Clin Gastroenterol Hepatol
Who Examines the Colon Matters More Than What Is Removed.

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Who examines the colon matters more than what is removed - Authors' reply.

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Gastroenterology
Comments on the Role of TL1A/DR3 Signaling and Th9 Cells in Crohn's Disease.

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Gastrointest Endosc
Endoscopic necrosectomy for walled-off pancreatic necrosis: Is it a game changer at all times?

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Methodologic considerations and future directions for cost-effectiveness analyses of cold versus hot snare polypectomy in small pedunculated polyps.

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Skill degradation, false positive burden & translational gap of AI-assisted colonoscopy.

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Temporal confounding and application bias in the evaluation of a self-assembling peptide for postendoscopic submucosal dissection bleeding.

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Gut
Nucleos(t)ide analogue therapy for EASL immune-tolerant phase hepatitis B.

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Potential of GDF15 goes beyond its role as a non-invasive biomarker for MASLD.

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Response to: 'Rectal versus colonic submucosal cancer rates and procedural outcomes in large non-pedunculated polyps: French ESD registry data' by Van der Voort <i>et al</i>.

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J Hepatol
Diet quality and physical activity lower alcohol-attributable liver-related mortality in US adults. Practical recommendations for clinicians.

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Early PoPH: Disease or Treatment Gap?

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Early portopulmonary hypertension and mortality: caution against treatment-conferred survival and immortal time-bias.

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